What is Dry Granulation?
Dry Granulation Definition | The roller compaction process consists of a combination of screw feed, compaction and milling systems. Screw feed system considerations include vertical, horizontal, tapered or angular screw feed mechanisms. Roll system design options include smooth, serrated or pocketed roll surfaces. These considerations combine with screw feed speed, roll speed and roll pressure and the specific blend characteristics to determine the compaction performance at the slip zone, nip zone and release zone. In the pharmaceutical industry roller compaction equipment is increasingly being used with Real Time Release Testing or Process Analytical Testing capability.
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This paper looks at optimization processes for roll compaction of pharmaceutical excipients methods. It determines the optimized process conditions for roll compaction and for pharmaceutical milling through a close examination of the correlation between the unit operations.
Dry Granulation Articles
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