Dry Granulation

What is Dry Granulation?

Dry Granulation Definition | The roller compaction process consists of a combination of screw feed, compaction and milling systems. Screw feed system considerations include vertical, horizontal, tapered or angular screw feed mechanisms. Roll system design options include smooth, serrated or pocketed roll surfaces. These considerations combine with screw feed speed, roll speed and roll pressure and the specific blend characteristics to determine the compaction performance at the slip zone, nip zone and release zone. In the pharmaceutical industry roller compaction equipment is increasingly being used with Real Time Release Testing or Process Analytical Testing capability.

Dry Granulation White Papers

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Dry Granulation
Dry Granulation

Basic Principles of Roller Compaction

dry granulation

A full understanding of powder flow behavior and the corresponding equipment options is essential when developing, optimizing or scaling up a drug product process. See our list of related equipment suppliers to find the right partner for your process.

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Dry Granulation
Dry Granulation

A Review: Industrial Process Validation of Solid Dosage Forms

dry granulation

This white paper discusses the fine powder flow phenomena in bins, hoppers and processing vessels. To get these insights tap or click on the image, pdf icon or text highlighted in blue.

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Dry Granulation
Dry Granulation

Simulation of Roll Compaction Bruno C. Hancock, PhD

dry granulation

This white paper discusses five fundamentals of effective blend sampling and methods to ensure your sampling process accurately demonstrates your blend quality.

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Dry Granulation
Dry Granulation

Optimization of Roll Compaction (Rcdg) Process for Poorly Flowable Antiviral Formulation

dry granulation

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The roll compaction/dry granulation (RCDG) process when optimized, reduces poor flowability. Operating parameter variables include roller speed, hydraulic pressure and granulator speed on a pharma roll compactor. Discover why using the RCDG process improves flowability.

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Dry Granulation
Dry Granulation

Roll Compaction of Pharmaceutical Excipients (Optimized Methods) by SHEN YU

dry granulation

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This paper looks at optimization processes for roll compaction of pharmaceutical excipients methods. It determines the optimized process conditions for roll compaction and for pharmaceutical milling through a close examination of the correlation between the unit operations.

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Dry Granulation Videos

Why Roller Compaction?

In a pharmaceutical development context it is the process where ingredients are blended together with force through compaction which results in a standardized size. Slugging and roller compaction are the two methods generally used in dry granulation. For more on this process watch the video. To source trusted peer recommended roller compactor / dry granulator machines and equipment, see here

Effective Roller Compaction Process in QbD

An Effective Roller Compaction Process in a Quality by Design (QbD) Environment

A full understanding of powder flow behavior and the corresponding equipment options is essential when developing, optimizing or scaling up a drug product process. See our list of related equipment suppliers to find the right partner for your process.

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Dry Granulation Articles

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How Smart Buyers Choose Pharmaceutical Equipment Suppliers 2017 Pharma Supplier Checklist

April 10th, 2017|0 Comments

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