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Extrusion Spheronisation | Suppliers – White Papers

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Extrusion Spheronisation | Suppliers – White Papers 2017-05-23T17:47:45+00:00

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Extrusion Spheronisation

What is Extrusion Spheronisation?

Extrusion Spheronization / Extrusion Spheronization Definition 

Hot melt extrusion is utilized in pharmaceutical solid oral dose processing to enable delivery of drugs with poor solubility and bioavailability. Hot melt extrusion has been shown to molecularly disperse poorly soluble drugs in a polymer carrier increasing dissolution rates and bioavailability. The process involves the application of heat, pressure and agitation to mix materials together and ‘extrude’ them through a die. Twin-screw high shear extruders blend materials and simultaneously break up particles. Hot melt extrusion is increasingly being used with real time release testing (RTRT) capability to improve process efficiencies.

Extrusion Spheronisation White Papers

Extrusion Spheronisation
Extrusion Spheronisation

Extrusion Spheronization – A Review

Extrusion Spheronisation

Monitoring Pharmaceutical Application Note Solvent Drying Processes Using the Thermo Scientific Prima PRO Process Mass Spectrometer. Touch or click PDF icon or image for more details.

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Extrusion Spheronisation
Extrusion Spheronisation

Preparation and Characterization of LVT Dry Granules

Extrusion Spheronisation

Preparation and Characterization of Levetiracetam (LVT) Dry Granules Using Continuous Twin Screw Granulation. Touch or click on the image, pdf icon or text highlighted in blue.

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Extrusion Spheronisation
Extrusion Spheronisation

Hot Melt Extrusion with BASF Pharma Polymers

Extrusion Spheronisation

Extrusion Compendium – An in depth look at extrusion including the advantages and disadvantages related to common and proven technologies for the manufacture of amorphous solid dispersions.

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Under Review -Extrusion Spheronisation
Under Review -Extrusion Spheronisation

Early Discovery Support

Extrusion Spheronisation

Hot-melt Extrusion in Early Discovery Support: phase-appropriate screens to minimize API use. Touch or click on the image, pdf icon or text highlighted in blue.

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Under Review - Extrusion Spheronisation
Under Review - Extrusion Spheronisation

Scale-up of the Melt Extrusion Process

Extrusion Spheronisation

Scale-up of the Melt Extrusion Process from Bench Scale to Pilot Scale Extruder by Equalizing Specific Mechanical Energy Inputs. Touch or click on the image, pdf icon or text highlighted in blue.

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Under Review - Extrusion Spheronisation
Under Review - Extrusion Spheronisation

Suitability Evaluation of Functional Excipients

Extrusion Spheronisation

Preparation and Characterization of Levetiracetam (LVT) Dry Granules Using Continuous Twin Screw Granulation. Touch or click on the image, pdf icon or text highlighted in blue.

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powder handling

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Extrusion Spheronisation Videos

Spheronization Equipment

Caleva – Spheronizer 500 is for production of pharmaceutical pellets. This machinery equipment is for the production of pharmaceutical pellets by extrusion and spheronization also called marumerization.

Thermo Scientific Hot Melt Extrusion

See an equipment demonstration of the thermo scientific hot melt extrusion process in this video clip.

Catalent: Hot Melt Extrusion Technology

This equipment formulates, develops and commercializes the hot melt extrusion processes and integrates these into differentiated final dosage forms. The technology works by enhancing solubility by producing a stable, amorphous solid dispersion, increased-energy form through a combination of the process and the chemical properties of the excipient.

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Extrusion Spheronisation Articles

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