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Milling Size Reduction

What Is Pharmaceutical Milling ?

Pharmaceutical Milling Definition | Pharmaceutical Milling is the process of using rotary cutters in pharmaceutical equipment machinery to remove materials from a workpiece by feeding in at an angle with the axis of the tool. Milling is used in pharmaceutical processing to break down and de-agglomorate powders and granules to a specific particle size range. The physical characteristics of the resulting powder can influence downstream processing steps such as blending and tablet compression and also in-vivo performance.

Typically the material to be filled is fed through a hopper, through gravity or vacuum feed, and passed through a milling chamber. The milling chamber consists of rotating sharp or blunt blades and a sizing screen. The type of blade, rotation speed and the dimensions of the pores of the sizing screen are all critical in producing a specific particle size for a product. The characteristics of the milled material are often critical to subsequent processing steps and are routinely tested in line or as an intermediate bulk. Increasingly, milling operation efficiency is being increased by the use of real time release testing (RTRT).

Milling Size Reduction White Papers

Milling Size Reduction
Milling Size Reduction

Effect of Size Reduction Parameters

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The white paper discusses the effect of size reduction parameters in pharmaceutical manufacturing process. Touch or click the image or PDF icon for more information.

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Milling Size Reduction
Milling Size Reduction

Development of Mechanistic Model

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This white paper discusses the development of mechanistic model for milling of roller compacted ribbons. To get these insights touch or click on the image, pdf icon or text highlighted in blue.

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Milling Size Reduction
Milling Size Reduction

Ribbon Mechanical Properties / Milling Parameters

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This white paper discusses ribbon mechanical properties and milling parameters that determine fines generation during dry granulation.

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Milling Size Reduction
Milling Size Reduction

Pharmaceutical Solids

This white paper looks in detail at pharmaceutical solids in relation to size, shape, and surface area. For more, touch or click on the image or PDF icon.

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Milling Size Reduction
Milling Size Reduction

Pharmaceutical Technology GMP

This white paper discusses different pharmaceutical technology GMP size reduction systems. For more information touch or click on the image or PDF icon.

milling size reduction

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Milling Size Reduction
Milling Size Reduction

Methods of Size Reduction Factors

This white paper looks at various methods of size reduction and factors affecting size reduction in pharmaceutics. Touch or click the image or PDF icon for more information.

milling size reduction

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High Shear Granulation Videos

Basics In Size Reduction

Basics In Size Reduction – Fine & Ultrafine Size Reduction. See our list of related pharmaceutical machine equipment suppliers to find the right partner for your process.

Basics In Size Reduction 2

Basics of Size Reduction-Coarse to Medium Grinding. See our list of related pharmaceutical machine equipment suppliers to find the right partner for your process.

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